Advanced Formula and Precision in Flow Control
•Composition: A unique blend of EVOH (Ethylene Vinyl Alcohol Copolymer), DMSO (Dimethyl Sulfoxide), and Tantalum.
•Non-Adhesive Formula: Ensures controlled and precise embolization, reducing the risk of non-target embolization.
•High Radiopacity: Tantalum provides excellent visibility under imaging, ensuring accurate deployment.
Optimal Outcomes for 3 Different Formulas
•Its non-adhesive nature ensures stable and cohesive embolus formation without compromising the vessel walls.
•Biocompatible: The materials used are safe and well-tolerated by the body.
•Versatile Use: Suitable for a wide range of neurovascular applications.
•Stable and Consistent: Provides reliable performance for every procedure.
Libro: Setting the Standard in Controlled Vascular Occlusion
The agent’s solubility in DMSO enables delivery through microcatheters, ensuring targeted application and reducing the risk of non-target embolization. The inclusion of Tantalum powder enhances radiopacity, allowing for real-time monitoring and precise placement, further ensuring procedural success.
Libro Non-Adhesive Embolization Agent represents a paradigm shift in vascular occlusion, combining Ethylene Vinyl Alcohol Copolymer (EVOH), Dimethyl Sulfoxide (DMSO), and Tantalum powder to deliver a state-of-the-art solution.
This unique blend ensures a stable and cohesive embolus formation upon contact with blood, while maintaining non-adhesive properties to preserve the integrity of the vessel walls. Libro’s EVOH component guarantees durability and biocompatibility, ensuring long-term patient safety.
The solubility in DMSO allows for delivery through microcatheters, enhancing the precision of application and minimizing the risk of non-target embolization. Additionally, the inclusion of Tantalum powder ensures superior radiopacity, providing clinicians with real-time monitoring capabilities and ensuring precise placement during procedures.
Choose Libro for a reliable, non-adhesive, and precisely controllable embolization agent, setting new standards in patient care and procedural success.
EVOH Base (Ethylene Vinyl Alcohol Copolymer)
•Stable Embolic Matrix: Once injected, the EVOH solution solidifies upon contact with blood or aqueous medium, forming an occlusive cast within the targeted vasculature.
•Non-Adhesive: Minimizes risk of catheter entrapment, enabling smoother microcatheter withdrawal post-embolization.
DMSO Solvent
•Uniform Dispersion: Maintains the EVOH in a liquid state until injection, allowing for precise and controlled delivery.
•Gradual Precipitation: The polymer solidifies from the outer surface inward, helping operators monitor and fine-tune deposition patterns.
Radiopacity
•Integrated Tantalum Powder (or similar radiopaque agent) ensures fluoroscopic visibility, enabling real-time feedback on embolic material positioning.
Product Specifications
Specification | Detail / Value |
Product Name | Libro Non-Adhesive Embolization Agent (EVOH-based liquid embolic with DMSO solvent and tantalum for radiopacity) |
Intended Use | Embolization of cerebral or peripheral arteriovenous malformations (AVMs), hypervascular tumors, or similar lesions |
Composition | EVOH (ethylene vinyl alcohol) copolymer, DMSO solvent, tantalum powder for radiopacity |
Viscosity Range | Varies by concentration of EVOH (low, medium, high viscosity) |
Polymerization Mechanism | Precipitation in blood upon DMSO diffusion, forming a non-adhesive solid cast in the lesion |
Delivery Method | Via microcatheter compatible with DMSO (e.g., 1.5–1.8F or 2.0–2.3F ID) |
Radiopacity | Tantalum provides fluoroscopic visibility throughout injection and polymerization |
Sterility | Sterile, Single Use |
Shelf Life | ~2–3 years if stored at 15–25 °C in sealed packaging |
Clinical Indications | AVM occlusion, tumor devascularization, dural AVFs, select peripheral or neurovascular lesions |
Contraindications | Vessels too small for microcatheter passage, high-flow fistulas (might require different approach), known DMSO allergy |
Ordering & Size Matrix
Viscosity Level | EVOH Concentration (%) | Tantalum Content (%) | Vial Volume (mL) | Product Code | Notes |
Low | 6 | 25 | 1.0 | LBR-L-6-25-1.0 | Lower viscosity, deeper penetration into fine feeders |
Low | 6 | 25 | 1.5 | LBR-L-6-25-1.5 | Slightly larger volume, same concentration |
Medium | 8 | 25 | 1.0 | LBR-M-8-25-1.0 | Balanced viscosity for moderate AVMs |
Medium | 8 | 25 | 1.5 | LBR-M-8-25-1.5 | Additional volume option |
High | 10 | 30 | 1.0 | LBR-H-10-30-1.0 | More viscous agent for larger or high-flow lesions |
High | 10 | 30 | 1.5 | LBR-H-10-30-1.5 | Greater volume for extensive devascularization |